ESMO 2021

VGEF antibody plus TKI: the conundrum continues

T-Dxd - a new standard for 2nd line HER2+ MBC

T-Dxd: New treatment paradigm for patients with metastatic HER2+ breast cancer

The game changer: Abiraterone in high risk M0 prostate cancer

Pembrolizumab adjuvant in stage II reduces the risk of recurrence, but long-term side effects are possible

Chemoimmunotherapy in 1st line is getting crowded

Long-term survival with double checkpoint-inhibition

My ESMO melanoma highlights

PORT: is the discussion really closed?

ESMO highlights: Spacing out Ipi; TKI drug holidays, QoL not affected by adjuvant IO

First study to report OS benefit with CDK4/6i in first line setting for postmenopausal patients

DESTINY Breast03: T-Dxd - a new standard for HER2+ MBC

KEYNOTE-355: Pembrolizumab A new option for TNBC

MONALEESA-2: Long Term 1st Line significant overall survival with ribociclib

T-Dxd: New treatment paradigm for patients with metastatic HER2+ breast cancer

Remarkable improvement of overall survival with ribociclib

New standard of care for HER2+ MBC

Ribociclib in 1st line: Long follow-up time confirms OS advantage

Two positive trials reinforce the role of Checkpoint-inhibitors in early and metastatic TNBC

Impressive new data on the improvement of PFS with T-Dxd in patients Her2+ mBC

ESMO21 highlights in metastatic and early breast cancer

MBC significant data: T-Dxd, Pembrolizumab, Ribciclib

Finally a survival benefit in 1st line metastatic TNBC

Management of Carcinomatous Meningitis (CM) in breast cancer patients

T-Dxd - a new standard for 2nd line HER2+ MBC

Dose escalation of everolimus in patients with metastatic breast cancer (mBC)

Survival data confirm pembrolizumab as standard of care

Large step forward in HER2+ MBC with T-Dxd

First study to report OS benefit with CDK4/6i in first line setting for postmenopausal patients

A new standard of care for TNBC

Becoming the standard of care for patients with HER2+ MBC

Remarkable survival benefit with Ribociclib defines a new standard of care for patients with HR+ mBC

Great results and further research

T-DXd: Impressive results show the potential of ADC technology

Ribociclib in 1st line: Lange Nachbeobachtungszeit bestätigt OS-Vorteil

Dés résultats impressionnants avec les T-DXd en 2ème ligne chez les patientes atteintes d’un cancer HER2-positif métastatique

Krok milowy w leczeniu zaawansowanego, HER2-dodatniego raka piersi

Nareszcie wydłużenie całkowitego czasu przeżycia w 1. linii leczenia zaawansowanego, potrójnie ujemnego raka piersi - KEYNOTE-355

Doua trialuri pozitive in tratamentului imunoonologic cu pembrolizumab la pacientele cu cancer mamar timpuriu si metastatic triplu negativ

Punti salienti nel carcinoma mammario metastatico e precoce

T-DXd: un nuevo estándar de tratamiento en pacientes con cáncer de mama metastásica HER2 en segunda línea

T-DXd: Beeindruckende Ergebnisse zeigen Potenzial der ADC-Technologie

Risultati straordinari con il T-DXd in seconda linea nelle pazienti con tumore della mammella metastatico HER2 positivo

Beneficiu ramarcabil cu Ribociclib in prima linie de tratatment , nou standard la paciente cu cancer mamar metastatic HR+, Her -

HER2+: Reduced duration of adjuvant Trastuzumab

TNBC: Carboplatinum in neoadjuvant therapy

TNBC: CPI performing in the neo-adjuvant setting

TNBC Benefit: Pembro + NACT; Carboplatinum

Trastuzumab + Lapatinib; reducing the duration of anti-HER2 treatment

Addition of Carbo-Platin with signifcant EFS advantage

Patient selection allows efficacy and deescalation

Extended adjuvant Letrozole with significant DFS benefit

Shortening the trastuzumab therapy to 6 months?

High risk patients deserve Pembro

Neoadjuvant Giredestrant showed anti-proliverative effect

Carboplatin, a new standard of care in early TNBC?

Verkürzung der Trastuzumab-Therapie auf 6 Monate?

Pembrolizumab - eine Option für high risk Pat.

Karboplatyna – nowy standard leczenia we wczesnym, potrójnie ujemnym raku piersi?

Giredestrant zeigt anti-proliverative Wirkung im neoadjuvanten Setting

Trastuzumab: Kombination mit Lapatinib und verkürzte HER2- Blockade

Estensione del letrozolo adiuvante con vantaggio significativo in DFS

Patientenselektion mit hoher Wirksamkeit und Deeskalation zugleich

Aggiunta di carboplatino neoadiuvante con vantaggio significativo in DFS

BFAST: The Challenge of new biomarkers for immunotherapy

Upcoming therapy options in oncogenic-driven NSCLC

IO combinations in advanced NSCLC - revolution and challenges at the same time

New options for 2nd line after IO-failure

Are vaccines the way forward after progressing on immunotherapy?

New opportunitiy to treat HER2-mutated lung cancer

KRASG12C and platinum doublet chemotherapy: does the backbone matter?

New 1st line option

Poziotinib in HER2 mutated lung cancer

VGEF antibody plus TKI: the conundrum continues

Failure to demonstrate PFS-improvement when combining bevacicumab and osimertinib

HER2 mutations: new opportunities effective

New options in salvage setting for EGFR-mutant patients

Potential new biomarker for immunotherapy

Gavo-cel dose escalation in refractory mesothelin-expressing solid tumors

Chemoimmunotherapy in 1st line is getting crowded

EGFR TKI plus VEGF inhibition

New ADC for lung cancer

A new treatment for HER2-mutated NSCLC

Trastuzumab Deruxtecan, a new option for HER2+ lung cancer

Cemiplimab + chemotherapy: 1st presentation of EMPOWER-Lung3 data

2nd line option after IO failure

Nuevas terapias en linea avanzada de pacientes con mutaciones de EGFR

Kein Vorteil für Anti-IL1 AK

Nuevas opciones terapéuticas en segunda linea tras fallo a inmunoterapia

le TdxD, nouvelle option pour les CBNPC HER2+?

Chemoimmuntherapie 1st line: Wohin führt POSEIDON?

Un nouveau traitement pour le CBNPC HER2-muté

HER2 Mutation: Drug-Immuno-Conjugates effektiv

Cemilimab + Chemotherapie: Erste Daten der EMPOWER-Lung3

CAR-T-Zell-Therapie auch bei refraktären Karzinompatienten?

Absence d'amélioration de la SSP en associant le bevacicumab et l'osimertinib

Neues AWK beim Lungenkarzinom

Immune checkpoint inhibitors - on the way to standard therapy in early stage NSCLC

Stage III NSCLC - the new stage IV ?!

PORT: is the discussion really closed?

Update on chemoradiation for stage III NSCLC

The power of randomization

Durvalumab consolidation in a real world setting

Update on IMpower010

IO mono-Induction: window of opportunity to guide immunotherapy

Inflection point in next generation drug development

COAST on the horizon

Endpoint pathological response in induction therapy with immun checkpoint inhibition

Wind of change?

Immunotherapy improves PFS after sequential or concomittant radiochemotherapy

Potential new standard of care in NSCLC

The benefit of adjuvant atezolizumab in PD-L1 low

New option in unresectable NSCLC?

Completing the picture

Zijn vaccins de toekomst na progressie op immunotherapie?

L'immunothérapie améliore la SSP après une radiochimiothérapie séquentielle ou concomitante

Postoperatie radiotherapie bij N2 ziekte: is de discussie nu echt gesloten?

Neue IO-Kombinationen vielversprechend

IMpower010 Update: Stellenwert von Atezolizumab bestätigt

IO Mono Induktion - Zeitfenster für Immuntherapie

Neue Horizonte durch COAST

Pathological Response als Endpunkt bei Induktionstherapie mit immuncheckpoint-Inhibition

KRASG12C en platinum doublet chemotherapie: maakt de combinatie wat uit?

Learnings from IMpower010

Quelle efficacité du durvalumab en pratique clinique?

nouve opzioni per lo NSCLC Stadio III inoperabile?

Update IMpower010

Update on important phase III trials

The tail matters even in ES-SCLC

la coda conta anche nel SCLC in malattia estesa

Actualizaciones en estudios fase III

NIVOTHYM: Immunotherapy for thymic tumors

Is there a role for immunotherapy for thymic tumors?

Quelle place de l’immunothérapie pour les tumeurs thymiques? Essai NIVOTHYM

New era in mesothelioma – stay tuned!

Langzeitüberleben durch IO

IO-IO, la strada da percorrere nel mesotelioma

Actualizaciones en estudios fase III

New data for BRAF-mutated melanoma patients

RELATIVITY-047: Subgroup updates; Enduring benefit and prolonged PFS2

MASTERKEY-265: Pembrolizumab +/- T-VEC

KEYNOTE-716: Adjuvant pembrolizumab in stage IIB/C

CheckMate 204: Brain metastases - Promising achievements

My ESMO melanoma highlights

Highlights from this year's ESMO

Additional efficacy and shifts in treatment options

New strategies for adjuvant stage II

Pembrolizumab is a good option for adjuvant stage IIB/C

LAG-3-blocking ab shows benefit in combination with Nivo

Nivo/Ipi for brain metastatses

No preference for sequential therapy

A 5 year update

No significant improvement

Promising data, but some questions remain

Pembrolizumab adjuvant in stage II reduces the risk of recurrence, but long-term side effects are possible

T-VEC is not a convincing partner for CPI

5 year update

First data using immunotherapy as an adjuvant mechanism in stage II

Sequencing - start with immunotherapy first

Personalized treatment for patients according to IFN-γ sign

ESMO 2021: updates on the SECOMBIT study

Pembro adj. im Stad. II verringert Rezidivrisiko, aber Langzeit-NW möglich

T-VEC überzeugt nicht als Partner für CPI

Pembro gute Option adjuvant im Stad. IIB/C

5 Jahres Update

ESMO 2021: aggiornamenti dello studio SECOMBIT

LAG-3-AK zeigt Benefit in Kombi mit Nivo

Keine Präferenz bei sequenzieller Therapie

Nivo-Ipi bei Hirnmetastasen

PRO results support adjuvant IO efficacy, some questions still open!

Maintaining the IO-combination with higher flexibility.

ESMO highlights: Spacing out Ipi; TKI drug holidays, QoL not affected by adjuvant IO

Dual immunotherapy update

HIF-2α- a promising target?

Quality of Life in adjuvant immunotherapy

Role of cytoreductive nephrectomy in patients treated with TKI/IO combination

Update adjuvant immunotherapy

Increased flexibility for side effects due to ipilimumab

Long-term survival with double checkpoint-inhibition

Spannende Daten, wenn auch nicht "game-changing"

Ipi mit festem Stellenwert beim aRCC

Höhere Flexibilität bei Nebenwirkungen durch Ipilimumab

HIF-2α - una diana prometedora?

NABUCCO: IPI matters – discussion on benefits in bladder cancer

VESPER: Do we have to intensify perioperative chemotherapy in bladder cancer?

Improving patients outcome in bladder cancer

ipilimumab-nivolumab opportunities for alternative regimens

Strong signal regarding PFS and OS in ddMVAC

Deciphering strategies for immunotherapy combinations

VESPER neoadjuvant chemotherapy phase 3 trial in MIBC

ESMO highlights: new combinations FGFRa, Pembro+sEphB4, ddMVAC ...

PD-L1 as predictor of survival in DANUBE phase III trial in metastatic urothelial carcinoma

ESMO21:The highlights of Bladder cancer

Novita’ in tema di tumori vescicali dal congresso ESMO 2021

PDL-1 como predictor de supervivencia en cáncer de vejiga metastásico. Analizando el estudio fase III DANUBE

Starkes Signal bezüglich PFS und OS bei ddMVAC

Ipilimumab-Nivolumab Möglichkeiten für alternative Regime

Mejorando el futuro de los pacientes con cáncer de vejiga.

Descifrando las estrategias para mejorar las combinaciones con inmunoterapia

STAMPEDE: Practice changing in high-risk non-metastatic M0 Pca

ARCHES & PEACE-1: From doublets to triplets in mHSPC?

COSMIC-021: mCRPC perspectives in later Lines.

Hope for patients with mCRPC

The game changer: Abiraterone in high risk M0 prostate cancer

Triplet or duplet for high-risk patients

New data change our practice in non-metastatic high-risk PC

Is triplet therapy the new SOC?

Is it really practice changing?

PEACE-1 phase 3 trial in metastatic CSPC

DS7300 - an exciting novel therapy in prostate cancer and beyond

DD-MVAC is the new SOC!

Chemo Upront: Consider combination with Abiraterone

PSMA – RLT is here!

Enzalutamide added to ADT shows clear survival benefit with longer follow-up in the ARCHES study

Survival benefit with triplet therapy for mHSPC

New promising Combination with Pembro and lu-PSMA

More data for extending Enzalutamide's label for mHSPC

Practice changing results for mHSCP

Combination therapies and new targeted therapies in advanced prostate cancer

Significant advances in M0 PCa

mHSPC: ADT alone is not enough!

STAMPEDE trial: new standard of care for localized high risk prostate cancer (ADT/RT/ABI)

PEACE-1 studien visar överlevnadsvinst med trippel behandling vid metastaserad hormonkänslig prostatacancer

Resultat från STAMPEDE öppnar för ny kombinationsbehandling vid icke metastaserad hormonkänslig prostatacancer

Hoffnung für Patienten mit mCRPC

Längre uppföljningstid I ARCHES-studien visar klar överlevnadsvinst med enzalutamid som tillägg till kastrationsbehandling vi nydiagnostiserad metastaserad hormonkänslig prostatacancer

Ein weiteres Puzzlestück für Zulassungserweiterung von Enzalutamide beim mHSPC

Triplet oder Duplette beim hochrisiko Patienten

Chemo Upfront: Kombination mit Abiraterone bedenken!

Kombinationsbehandlingar och nya riktade terapier vid avancerad prostatacancer

Neue vielversprechende Kombination mit Pembro und lu-PSMA

Σημαντικό όφελος με την προσθήκη άμπιρατερονης Στην θεραπεία ασθενών με υψηλού ρίσκου τοπικό περιοχικο Καρκίνο προστάτη

Μεταστατικός ορμόνο ευαίσθητος καρκίνος προστάτη: Η θεραπεία με lhrh ανάλογα μόνο δεν είναι αρκετή

CAR-T-Zell-Therapie auch bei refraktären Karzinompatienten?

Covid19 & Cancer: updates from ESMO 2021