ASCO 2022

Paradigm shift in breast cancer: Where do we use the treatment option? How do we test HER2 status? How can we manage toxicity?

CDK4/6i switch: who benefits from switching the CDK4/6 inhibitor?

What are the cosenquences of the new OS data for CDK4/6 inhibitor therapy?

More data needed: Are the results clinical meaningful? How can SG fit in the therapy algorithm?

Transatlantic differences in ADC side effects management

Determining HER2 receptor expression: How do we target the HER2-low subtype?

Patients perspectives: ADCs - how do manage the new, smart chemotherapies?

ADCs & CDK4/6i - paradigm shifts and therapy switches in metastatic breast cancer

What clincial value has statistical signifcance? How can we improve trial design to become statistical and clinical significant?

How to determine progress of disease? How to proceed therapy after CDK4/6i inhibitor? When should we change the endocrine combination partner?

Additional administration of ribociclib improves PFS after prior CDK4/6i therapy.

Practice changing data

Benefit of CDK4/6 Switch after Progression

My ASCO22 highlights in metastatic breast cancer

Impressive and practice changing data of ADCs mark the beginning of a long success story

Discontiunation of trial is disappointing despite negative results

SG is a new therapy option for HR+/HER2- MBC patients

Combi SERD + Palbo reduces proliferation better than SERD + anastrozole

Gamechanger in breast cancer

T-DxD should be the new SoC for Her2low MBC patients

Combination of ctDNA and TKa assesment may improve outcome prediction of RIB+LET treatment

Disappoiting final OS data and its implications for our patients

Revolution in the field of HR+ disease

Good therapeutic option in HR+ HER2- mBC after failure of endocrine therapy

Option for overcoming endocrine resistance?

Patritumab Deruxtecan: HER3-targeted ADC in HER3 -expressing mBC

Improvment of PFS & OS with activated alteration PIK3CA/AKT1/PTEN pathway.

Breakthrough news with antibody drug conjugate

Smart chemotherapy improves PFS

Exciting and practice changing news for HR+/Her2low MBC patients

Fascinating data of ADCs in breast cancer at ASCO22

No effect for local treatment of metastasis

Sacituzumab govitecan improves PCr in patients with localized TNBC

Endocrine therapy alone is important in treatment of elderly patients

Exciting advances across a wide subset of breast cancers

New SoC for large subpopulation of breast cancer patients

ADC: future therapeutic option in advanced HR+/HER2 BC

First evidence on benefit of CDK4/6 inhibitors beyond progression

Palbociclib - Overall survival data

No changes in clinical practice after new CDK4/6i-data

Possible explanations of the negative study

New standard of care for HR+/Her2low patients

New agents for the clincial practice

Oligometastasis: no advantage of additional radiotherapy

SG may be a good option for pre-treated HR+/Her2- pts

SG come nuova opzione di cura per le pazienti con tumore mammario metastatico HR+/HER2-

Il sacituzumab govitecan migliora il PFS nei tumori endocrino-responsivi

Novità entusiasmanti e practice changing per le pazienti con tumore mammario metastatico HR+/Her2low

Les nouvelles données impressionnantes des ADC à l’ASCO 2022 : le début d'une longue histoire de succès

Pierwsze dane nt. skuteczności inhibitorów CDK4/6 po progresji

La valutazione combinata di ctDNA e TKa può aiutare a migliorare la selezione delle pazienti trattate con RIB+LET

Una rivoluzione per il tumore mammario endocrino-responsivo ed HER2 low

Noutăți inovatoare cu conjugatul de medicamente cu anticorpi

Nowy standard dla znaczącej subopulacji chorych na raka piersi

I nuovi impressionanti risultati degli ADC a l’ASCO 2022 : l’inizio di una lunga storia di successi.

ADCs en cáncer de mama con receptores hormonales positivos

PALOMA2 e MAINTAIN: cosa cambia nella pratica clinica?

Adding towards deescalation in luminal A EBC by omitting radiotherapy

Long term overall survival benefit of Denosumab in addition to improved bone health

CT benefit for elderly patients, if they are able to complete therapy.

Neoadjuvant Pembro decreased RCB. SG - first promising ADC in early TNBC!

Ovarian function suppression - it is here to stay!

My ASCO22 highlights in early breast cancer

High concordance of local, central IHC and RT-PCR for ER, PR and HER2

Combi SERD + Palbo redzuert proliferation better than SERD + anastrozole

Immunotherapy - Part 1

Molecular landscape - Part 2

Immunotherapy - Part 2

Molecular landscape - Part 1

CLN-081 is a promising new agent for EGFR exon 20 insertion NSCLC

COSMIC-021: Not practice-changing, but interesting results

New components and therapies for advanced NSCLC

New treatment options for METexon 14 skipping: amivantamab

Strategies for PD-L1 > 50%

PD-L1 over 50%: Chemo-IO or IO?

Is adagrasib an alternative to sotorasib?

CLN-081 for patients with metastatic NSCLC and an EGFRexon20 insertion

Options after progression to chemo/IO and for KRASG12C mut

Role of IO and chemo-IO in patients with PD-L1 > 50%

KRASG12C mutation: Adagrasib is comparabale to sotorasib

Multiple aquired resistance mutations may drive disease progression

Bispecific Antibodies - the cMET field is moving

Promising results for pre-treated patients with KRASG12C mutation

A chemo-free option in patients with EGFR-mutation

In the second line: Options for Immunotherapy resistance and KRAS mutations

Amivantamab as a future option for METex14 patients?

New option in patients harboring METex14 mutation

L’adagrasib, inhibiteur de la mutation KRASG12C: une efficacité comparable à celle du sotorasib?

CLN-081 voor patienten met gemetastaseerd NSCLC en een EGFRexon20 insertie

Segunda Linea: opciones tras resistencia a inmunoterapia y mutaciones de KRAS

Die Rolle von IO und Chemo-IO bei Patienten mit PD-L1 > 50%

Bispezifische Antikörper - Neues von CHRYSALIS

Nuevas terapias para el CPCNP avanzado

Nieuwe behandelopties voor METexon 14 skipping: amivantamab

COSMIC-021: Nicht praxisverändernd, aber interessante Resultate

Une nouvelle option, l’amivantamab, en situation de délétion dans l’exon 14 de MET

PD-L1 über 50 % - was tun?

Was tun nach Versagen einer Chemoimmun-Therapie?

Veelbelovende resultaten voor voorbehandelde patienten met een KRAS G12C mutatie

Neoadjuvant and adjuvant therapy - Part 1

Neoadjuvant and adjuvant therapy - Part 2

NADIM-II strengthens the findings from CheckMate-816

CheckMate-816: Neoadjuvant therapy

Perspectives on multimodality

New treatment approaches in Stage III

A new option in neoadjuvant chemoimmunotherapy

Chimiothérapie néoadjuvante des stades III , vers un nouveau standard de soins

Neue Ansätze im Stadium III

SKYSCRAPER-02: Subgroups could be important

No benefit for tiragolumab / novel anti-PD-1 mAB serplulimab effective

Immuncheckpoint-inhibitor therapy

SCLC-Update: No benefit with Tiragolumab/Chemo-IO is here to stay

Le Tiragolumab n’apporte pas de bénéfice à la chimioimmunothérapie de première ligne/ Une nouvelle phase III en faveur de la chimio immunothérapie de première ligne

mCRPC: LuPSMA - new treatment option in mCRPC

PARP inhibitors in mCRPC: Do we need more genetic testing?

mHSPC: Transatlantic differences in genetic testing & updates in doublets vs. triplets

Frequent imaging for early detection of metastases in nmCRPC.

TheraP shows no difference in overall survival between cabazitaxel and LuPSMA

SUV mean at PET images as a prognostic tool for PSMA treatment

No big scoop, but encouraging results

Phase 1 study on combining LuPSMA treatment with immunotherapy

Ongoing trial invetiagting the impact of Bavdegalutamide on Arbiraterone restistance in pts with PCa

The highlights in GU cancers of ASCO22

SUVmean is highly predictive of better PFS and OS

Arbiraterone + Olaparib: Is it synergistic?

The efficacy of doublets in mHSPC

SHR3680 - do we need a new androgen receptor inhibitor

Lu-PSMA in the third line

GGT impacts PCa patients care

3 year overall survival of TheraP study

Lu-PSMA effective regardless of prior or concomitant therapy

Further updates from the VISION trial

LuPSMA & cabazitaxel are better than SoC alone

Value of triple-therapy - complimentary study to ARASENS trial

ADT alone is no longer standard of care

PFS good surrogate endpoint for overall survival

Surrogate endpoints in mHSPC

Kvantifiering av PMSA PET upptaget som prognostisk markör i VISION studien

Lo mas destacado en tumores GU en ASCO 2022

Treårs överlevnadsresultat i TheraP studien.

Kombination av 177-LU-PSMA-617 och pembrolizumab I Fas 1 prövning

Tidigare endpoints I mHSPC studier

Pas de nouvelles sensationnelles mais des données encourageantes

EVEREST: Inisghts from the negative trial

The relevance of quality of life in kidney cancer!

Combination Therapy is State of the Art in Metastatic Renal Cell Carcinoma.

What are the consequences for future trial design?

Should we be looking at Everolimus in the future?

The highlights in GU cancers of ASCO22

Combi Axi + Pembro also successful with good risk profile

Importance of health related quality of life

Should Everolimus be revisited for high-risk patients?

Belzutifann shows good tumor activity in renal cancer

Clear evidence for durable benefit for patients with von Hippel-Lindau disesase

QoL & DepOR correlate with clinical outcomes - reminder for future trial designs

Depth of remission in firstline

PSMA-PET may improve imaging of clear cell RCC

Lo mas destacado en tumores GU en ASCO 2022

Pas de nouvelles sensationnelles mais des données encourageantes

The role of systemic treatment in the pre-operative setting and updates on Avelumab maintenance

New data on TKi utilization in bladder cancer

ADCs: do we enter a new era of therapy for urothelial cancer?

My highlights of metastasized urothelial cancer

Investigating sasanlimab in BCG-unresponsive NMIBC

My highlights in localized urothelial cancer

Exciting future for ADCs

BCG failure

The highlights in GU cancers of ASCO22

The end of of VEGF-targeted therapy in urothelial cancer?

Maintenance concepts

ADCs: News from ASCO 2022

Perioperative immuno-chemotherapy in MIBC

No big scoop, but encouraging results

Lo mas destacado en tumores GU en ASCO 2022

Σημαντικά μηνύματα για τον ουροθηλιακό καρκίνο από το ASCO 2022

Radiotherapy as a new standard for cisplatin ineligible patients

Precision oncology - NTRK worth to search the patients

News from Sarcoma

Few testicular tumors after 5 years

Opportunities & challenges of cancer genetics

Systemic therapy