ASCO 2022

Transatlantic differences in ADC side effects management

CDK4/6i switch: who benefits from switching the CDK4/6 inhibitor?

What are the cosenquences of the new OS data for CDK4/6 inhibitor therapy?

More data needed: Are the results clinical meaningful? How can SG fit in the therapy algorithm?

Paradigm shift in breast cancer: Where do we use the treatment option? How do we test HER2 status? How can we manage toxicity?

ADCs & CDK4/6i - paradigm shifts and therapy switches in metastatic breast cancer

How to determine progress of disease? How to proceed therapy after CDK4/6i inhibitor? When should we change the endocrine combination partner?

What clincial value has statistical signifcance? How can we improve trial design to become statistical and clinical significant?

Determining HER2 receptor expression: How do we target the HER2-low subtype?

Patients perspectives: ADCs - how do manage the new, smart chemotherapies?

Combination of ctDNA and TKa assesment may improve outcome prediction of RIB+LET treatment

Breakthrough news with antibody drug conjugate

Option for overcoming endocrine resistance?

Additional administration of ribociclib improves PFS after prior CDK4/6i therapy.

Exciting advances across a wide subset of breast cancers

New standard of care for HR+/Her2low patients

New SoC for large subpopulation of breast cancer patients

Smart chemotherapy improves PFS

Benefit of CDK4/6 Switch after Progression

Impressive and practice changing data of ADCs mark the beginning of a long success story

Sacituzumab govitecan improves PCr in patients with localized TNBC

Oligometastasis: no advantage of additional radiotherapy

Revolution in the field of HR+ disease

T-DxD should be the new SoC for Her2low MBC patients

SG may be a good option for pre-treated HR+/Her2- pts

SG is a new therapy option for HR+/HER2- MBC patients

My ASCO22 highlights in metastatic breast cancer

Palbociclib - Overall survival data

No changes in clinical practice after new CDK4/6i-data

Combi SERD + Palbo reduces proliferation better than SERD + anastrozole

Good therapeutic option in HR+ HER2- mBC after failure of endocrine therapy

Exciting and practice changing news for HR+/Her2low MBC patients

No effect for local treatment of metastasis

Endocrine therapy alone is important in treatment of elderly patients

Gamechanger in breast cancer

Practice changing data

Patritumab Deruxtecan: HER3-targeted ADC in HER3 -expressing mBC

First evidence on benefit of CDK4/6 inhibitors beyond progression

ADC: future therapeutic option in advanced HR+/HER2 BC

New agents for the clincial practice

Improvment of PFS & OS with activated alteration PIK3CA/AKT1/PTEN pathway.

Discontiunation of trial is disappointing despite negative results

Fascinating data of ADCs in breast cancer at ASCO22

Disappoiting final OS data and its implications for our patients

Possible explanations of the negative study

La valutazione combinata di ctDNA e TKa può aiutare a migliorare la selezione delle pazienti trattate con RIB+LET

I nuovi impressionanti risultati degli ADC a l’ASCO 2022 : l’inizio di una lunga storia di successi.

Il sacituzumab govitecan migliora il PFS nei tumori endocrino-responsivi

Les nouvelles données impressionnantes des ADC à l’ASCO 2022 : le début d'une longue histoire de succès

Nowy standard dla znaczącej subopulacji chorych na raka piersi

Novità entusiasmanti e practice changing per le pazienti con tumore mammario metastatico HR+/Her2low

Una rivoluzione per il tumore mammario endocrino-responsivo ed HER2 low

SG come nuova opzione di cura per le pazienti con tumore mammario metastatico HR+/HER2-

ADCs en cáncer de mama con receptores hormonales positivos

Noutăți inovatoare cu conjugatul de medicamente cu anticorpi

PALOMA2 e MAINTAIN: cosa cambia nella pratica clinica?

Pierwsze dane nt. skuteczności inhibitorów CDK4/6 po progresji

Ovarian function suppression - it is here to stay!

CT benefit for elderly patients, if they are able to complete therapy.

Adding towards deescalation in luminal A EBC by omitting radiotherapy

Long term overall survival benefit of Denosumab in addition to improved bone health

Neoadjuvant Pembro decreased RCB. SG - first promising ADC in early TNBC!

Combi SERD + Palbo redzuert proliferation better than SERD + anastrozole

My ASCO22 highlights in early breast cancer

High concordance of local, central IHC and RT-PCR for ER, PR and HER2

Molecular landscape - Part 2

Molecular landscape - Part 1

Immunotherapy - Part 2

Immunotherapy - Part 1

New treatment options for METexon 14 skipping: amivantamab

CLN-081 is a promising new agent for EGFR exon 20 insertion NSCLC

New components and therapies for advanced NSCLC

COSMIC-021: Not practice-changing, but interesting results

Amivantamab as a future option for METex14 patients?

New option in patients harboring METex14 mutation

CLN-081 for patients with metastatic NSCLC and an EGFRexon20 insertion

In the second line: Options for Immunotherapy resistance and KRAS mutations

PD-L1 over 50%: Chemo-IO or IO?

A chemo-free option in patients with EGFR-mutation

Strategies for PD-L1 > 50%

Promising results for pre-treated patients with KRASG12C mutation

Is adagrasib an alternative to sotorasib?

Options after progression to chemo/IO and for KRASG12C mut

Role of IO and chemo-IO in patients with PD-L1 > 50%

Bispecific Antibodies - the cMET field is moving

Multiple aquired resistance mutations may drive disease progression

KRASG12C mutation: Adagrasib is comparabale to sotorasib

COSMIC-021: Nicht praxisverändernd, aber interessante Resultate

L’adagrasib, inhibiteur de la mutation KRASG12C: une efficacité comparable à celle du sotorasib?

Segunda Linea: opciones tras resistencia a inmunoterapia y mutaciones de KRAS

PD-L1 über 50 % - was tun?

CLN-081 voor patienten met gemetastaseerd NSCLC en een EGFRexon20 insertie

Une nouvelle option, l’amivantamab, en situation de délétion dans l’exon 14 de MET

Die Rolle von IO und Chemo-IO bei Patienten mit PD-L1 > 50%

Veelbelovende resultaten voor voorbehandelde patienten met een KRAS G12C mutatie

Bispezifische Antikörper - Neues von CHRYSALIS

Was tun nach Versagen einer Chemoimmun-Therapie?

Nuevas terapias para el CPCNP avanzado

Nieuwe behandelopties voor METexon 14 skipping: amivantamab

Neoadjuvant and adjuvant therapy - Part 2

Neoadjuvant and adjuvant therapy - Part 1

Perspectives on multimodality

NADIM-II strengthens the findings from CheckMate-816

New treatment approaches in Stage III

A new option in neoadjuvant chemoimmunotherapy

CheckMate-816: Neoadjuvant therapy

Neue Ansätze im Stadium III

Chimiothérapie néoadjuvante des stades III , vers un nouveau standard de soins

SKYSCRAPER-02: Subgroups could be important

No benefit for tiragolumab / novel anti-PD-1 mAB serplulimab effective

SCLC-Update: No benefit with Tiragolumab/Chemo-IO is here to stay

Immuncheckpoint-inhibitor therapy

Le Tiragolumab n’apporte pas de bénéfice à la chimioimmunothérapie de première ligne/ Une nouvelle phase III en faveur de la chimio immunothérapie de première ligne

mCRPC: LuPSMA - new treatment option in mCRPC

mHSPC: Transatlantic differences in genetic testing & updates in doublets vs. triplets

PARP inhibitors in mCRPC: Do we need more genetic testing?

GGT impacts PCa patients care

ADT alone is no longer standard of care

3 year overall survival of TheraP study

The efficacy of doublets in mHSPC

PFS good surrogate endpoint for overall survival

Ongoing trial invetiagting the impact of Bavdegalutamide on Arbiraterone restistance in pts with PCa

Lu-PSMA in the third line

Value of triple-therapy - complimentary study to ARASENS trial

LuPSMA & cabazitaxel are better than SoC alone

SUVmean is highly predictive of better PFS and OS

Phase 1 study on combining LuPSMA treatment with immunotherapy

Arbiraterone + Olaparib: Is it synergistic?

TheraP shows no difference in overall survival between cabazitaxel and LuPSMA

Frequent imaging for early detection of metastases in nmCRPC.

Surrogate endpoints in mHSPC

No big scoop, but encouraging results

SHR3680 - do we need a new androgen receptor inhibitor

The highlights in GU cancers of ASCO22

Further updates from the VISION trial

SUV mean at PET images as a prognostic tool for PSMA treatment

Lu-PSMA effective regardless of prior or concomitant therapy

Kvantifiering av PMSA PET upptaget som prognostisk markör i VISION studien

Pas de nouvelles sensationnelles mais des données encourageantes

Treårs överlevnadsresultat i TheraP studien.

Lo mas destacado en tumores GU en ASCO 2022

Kombination av 177-LU-PSMA-617 och pembrolizumab I Fas 1 prövning

Tidigare endpoints I mHSPC studier

What are the consequences for future trial design?

The relevance of quality of life in kidney cancer!

Combination Therapy is State of the Art in Metastatic Renal Cell Carcinoma.

EVEREST: Inisghts from the negative trial

Belzutifann shows good tumor activity in renal cancer

Depth of remission in firstline

QoL & DepOR correlate with clinical outcomes - reminder for future trial designs

Should Everolimus be revisited for high-risk patients?

Should we be looking at Everolimus in the future?

Combi Axi + Pembro also successful with good risk profile

The highlights in GU cancers of ASCO22

Importance of health related quality of life

Clear evidence for durable benefit for patients with von Hippel-Lindau disesase

PSMA-PET may improve imaging of clear cell RCC

Pas de nouvelles sensationnelles mais des données encourageantes

Lo mas destacado en tumores GU en ASCO 2022

New data on TKi utilization in bladder cancer

ADCs: do we enter a new era of therapy for urothelial cancer?

The role of systemic treatment in the pre-operative setting and updates on Avelumab maintenance

Exciting future for ADCs

My highlights in localized urothelial cancer

The end of of VEGF-targeted therapy in urothelial cancer?

Perioperative immuno-chemotherapy in MIBC

BCG failure

ADCs: News from ASCO 2022

My highlights of metastasized urothelial cancer

No big scoop, but encouraging results

The highlights in GU cancers of ASCO22

Maintenance concepts

Investigating sasanlimab in BCG-unresponsive NMIBC

Σημαντικά μηνύματα για τον ουροθηλιακό καρκίνο από το ASCO 2022

Lo mas destacado en tumores GU en ASCO 2022

Systemic therapy

Radiotherapy as a new standard for cisplatin ineligible patients

News from Sarcoma

Few testicular tumors after 5 years

Precision oncology - NTRK worth to search the patients

Opportunities & challenges of cancer genetics